Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 363463..364106 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag QRF07_RS01590 Protein ID WP_003401566.1
Coordinates 363681..364106 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag QRF07_RS01585 Protein ID WP_003401563.1
Coordinates 363463..363684 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS01560 (QRF07_01560) 358582..359385 - 804 WP_003401540.1 Stf0 family sulphotransferase -
QRF07_RS01565 (QRF07_01565) 359395..360792 - 1398 WP_003401544.1 sulfatase -
QRF07_RS01570 (QRF07_01570) 360971..362746 + 1776 WP_010886074.1 PE family protein -
QRF07_RS01575 (QRF07_01575) 362889..363116 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
QRF07_RS01580 (QRF07_01580) 363113..363415 + 303 WP_003401560.1 toxin-antitoxin system toxin -
QRF07_RS01585 (QRF07_01585) 363463..363684 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
QRF07_RS01590 (QRF07_01590) 363681..364106 + 426 WP_003401566.1 PIN domain nuclease Toxin
QRF07_RS01595 (QRF07_01595) 364242..364874 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
QRF07_RS01600 (QRF07_01600) 364871..365779 + 909 WP_003900117.1 protochlorophyllide reductase -
QRF07_RS01605 (QRF07_01605) 365787..366377 - 591 WP_229298012.1 hypothetical protein -
QRF07_RS01610 (QRF07_01610) 366370..366420 - 51 Protein_318 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T283992 WP_003401566.1 NZ_CP127277:363681-364106 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT283992 WP_003401563.1 NZ_CP127277:363463-363684 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References