Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 363463..364106 | Replicon | chromosome |
Accession | NZ_CP127277 | ||
Organism | Mycobacterium tuberculosis strain 25421 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFB8 |
Locus tag | QRF07_RS01590 | Protein ID | WP_003401566.1 |
Coordinates | 363681..364106 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | O07227 |
Locus tag | QRF07_RS01585 | Protein ID | WP_003401563.1 |
Coordinates | 363463..363684 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRF07_RS01560 (QRF07_01560) | 358582..359385 | - | 804 | WP_003401540.1 | Stf0 family sulphotransferase | - |
QRF07_RS01565 (QRF07_01565) | 359395..360792 | - | 1398 | WP_003401544.1 | sulfatase | - |
QRF07_RS01570 (QRF07_01570) | 360971..362746 | + | 1776 | WP_010886074.1 | PE family protein | - |
QRF07_RS01575 (QRF07_01575) | 362889..363116 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | - |
QRF07_RS01580 (QRF07_01580) | 363113..363415 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | - |
QRF07_RS01585 (QRF07_01585) | 363463..363684 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | Antitoxin |
QRF07_RS01590 (QRF07_01590) | 363681..364106 | + | 426 | WP_003401566.1 | PIN domain nuclease | Toxin |
QRF07_RS01595 (QRF07_01595) | 364242..364874 | + | 633 | WP_003905275.1 | TetR/AcrR family transcriptional regulator | - |
QRF07_RS01600 (QRF07_01600) | 364871..365779 | + | 909 | WP_003900117.1 | protochlorophyllide reductase | - |
QRF07_RS01605 (QRF07_01605) | 365787..366377 | - | 591 | WP_229298012.1 | hypothetical protein | - |
QRF07_RS01610 (QRF07_01610) | 366370..366420 | - | 51 | Protein_318 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15713.90 Da Isoelectric Point: 5.6002
>T283992 WP_003401566.1 NZ_CP127277:363681-364106 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
Download Length: 426 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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