Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3755482..3756011 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag QRF08_RS17730 Protein ID WP_003417760.1
Coordinates 3755754..3756011 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag QRF08_RS17725 Protein ID WP_003417757.1
Coordinates 3755482..3755757 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS17690 (QRF08_17690) 3752055..3752744 - 690 WP_003917774.1 BBE domain-containing protein -
QRF08_RS17695 (QRF08_17695) 3752931..3753302 - 372 WP_003417739.1 FAD-binding protein -
QRF08_RS17700 (QRF08_17700) 3753200..3753418 - 219 WP_157132559.1 hypothetical protein -
QRF08_RS17705 (QRF08_17705) 3753445..3753705 - 261 WP_003417741.1 hypothetical protein -
QRF08_RS17710 (QRF08_17710) 3753820..3754209 + 390 WP_003417745.1 DUF732 domain-containing protein -
QRF08_RS17715 (QRF08_17715) 3754223..3754516 - 294 WP_003417749.1 DUF3017 domain-containing protein -
QRF08_RS17720 (QRF08_17720) 3754513..3755358 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
QRF08_RS17725 (QRF08_17725) 3755482..3755757 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
QRF08_RS17730 (QRF08_17730) 3755754..3756011 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
QRF08_RS17735 (QRF08_17735) 3756053..3757243 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
QRF08_RS17740 (QRF08_17740) 3757360..3757728 + 369 WP_003417765.1 FHA domain-containing protein -
QRF08_RS17745 (QRF08_17745) 3757725..3758276 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
QRF08_RS17750 (QRF08_17750) 3758283..3758864 - 582 WP_003417769.1 ATP/GTP-binding protein -
QRF08_RS17755 (QRF08_17755) 3758845..3759213 - 369 WP_003417772.1 DUF742 domain-containing protein -
QRF08_RS17760 (QRF08_17760) 3759191..3759583 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T283986 WP_003417760.1 NZ_CP127276:3755754-3756011 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT283986 WP_003417757.1 NZ_CP127276:3755482-3755757 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References