283983

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3167847..3168534 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag QRF08_RS15145 Protein ID WP_003414624.1
Coordinates 3168091..3168534 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag QRF08_RS15140 Protein ID WP_003414620.1
Coordinates 3167847..3168104 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS15120 (QRF08_15120) 3163167..3164021 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
QRF08_RS15125 (QRF08_15125) 3164077..3165240 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
QRF08_RS15130 (QRF08_15130) 3165257..3166471 - 1215 WP_003414610.1 zinc metalloprotease Rip -
QRF08_RS15135 (QRF08_15135) 3166479..3167720 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
QRF08_RS15140 (QRF08_15140) 3167847..3168104 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
QRF08_RS15145 (QRF08_15145) 3168091..3168534 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS15150 (QRF08_15150) 3168614..3169276 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
QRF08_RS15155 (QRF08_15155) 3169372..3169563 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
QRF08_RS15160 (QRF08_15160) 3169895..3171643 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
QRF08_RS15165 (QRF08_15165) 3171739..3172320 + 582 WP_003414644.1 fasciclin domain-containing protein -
QRF08_RS15170 (QRF08_15170) 3172420..3172686 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T283983 WP_003414624.1 NZ_CP127276:3168091-3168534 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT283983 WP_003414620.1 NZ_CP127276:3167847-3168104 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References