Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3162246..3162794 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag QRF08_RS15115 Protein ID WP_003414602.1
Coordinates 3162531..3162794 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag QRF08_RS15110 Protein ID WP_003414599.1
Coordinates 3162246..3162527 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS15085 (QRF08_15085) 3157869..3158726 - 858 WP_003899513.1 type I methionyl aminopeptidase -
QRF08_RS15090 (QRF08_15090) 3158768..3159352 - 585 WP_003414585.1 DUF1707 domain-containing protein -
QRF08_RS15095 (QRF08_15095) 3159456..3159704 + 249 WP_003913411.1 antitoxin VapB23 -
QRF08_RS15100 (QRF08_15100) 3159701..3160081 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
QRF08_RS15105 (QRF08_15105) 3160163..3161974 - 1812 WP_003414596.1 penicillin-binding protein -
QRF08_RS15110 (QRF08_15110) 3162246..3162527 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
QRF08_RS15115 (QRF08_15115) 3162531..3162794 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRF08_RS15120 (QRF08_15120) 3163167..3164021 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
QRF08_RS15125 (QRF08_15125) 3164077..3165240 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
QRF08_RS15130 (QRF08_15130) 3165257..3166471 - 1215 WP_003414610.1 zinc metalloprotease Rip -
QRF08_RS15135 (QRF08_15135) 3166479..3167720 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T283982 WP_003414602.1 NZ_CP127276:3162531-3162794 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT283982 WP_003414599.1 NZ_CP127276:3162246-3162527 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References