Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2348918..2349613 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QRF08_RS11025 Protein ID WP_003905754.1
Coordinates 2348918..2349352 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag QRF08_RS11030 Protein ID WP_003410814.1
Coordinates 2349359..2349613 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS11015 (QRF08_11015) 2345072..2348113 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
QRF08_RS11020 (QRF08_11020) 2348106..2348939 + 834 WP_003899172.1 SWIM zinc finger family protein -
QRF08_RS11025 (QRF08_11025) 2348918..2349352 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS11030 (QRF08_11030) 2349359..2349613 - 255 WP_003410814.1 antitoxin Antitoxin
QRF08_RS11035 (QRF08_11035) 2349629..2349886 - 258 WP_003410816.1 hypothetical protein -
QRF08_RS11040 (QRF08_11040) 2350297..2351558 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
QRF08_RS11045 (QRF08_11045) 2352191..2352487 + 297 WP_003410820.1 PE family protein -
QRF08_RS11050 (QRF08_11050) 2352543..2353274 + 732 WP_003900467.1 PPE family protein -
QRF08_RS11055 (QRF08_11055) 2353815..2354561 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T283968 WP_003905754.1 NZ_CP127276:c2349352-2348918 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT283968 WP_003410814.1 NZ_CP127276:c2349613-2349359 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References