Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2305663..2306299 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag QRF08_RS10830 Protein ID WP_003410654.1
Coordinates 2305889..2306299 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag QRF08_RS10825 Protein ID WP_003410651.1
Coordinates 2305663..2305896 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS10810 (QRF08_10810) 2301120..2301512 + 393 WP_229303073.1 metal ABC transporter permease -
QRF08_RS10815 (QRF08_10815) 2301513..2301917 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
QRF08_RS10820 (QRF08_10820) 2302001..2305585 - 3585 WP_003910889.1 cobaltochelatase subunit CobN -
QRF08_RS10825 (QRF08_10825) 2305663..2305896 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
QRF08_RS10830 (QRF08_10830) 2305889..2306299 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
QRF08_RS10835 (QRF08_10835) 2306283..2307374 + 1092 WP_003900454.1 precorrin-3B synthase -
QRF08_RS10840 (QRF08_10840) 2307384..2308010 + 627 WP_003410658.1 precorrin-8X methylmutase -
QRF08_RS10845 (QRF08_10845) 2308007..2309533 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
QRF08_RS10850 (QRF08_10850) 2309479..2310702 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T283967 WP_003410654.1 NZ_CP127276:2305889-2306299 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT283967 WP_003410651.1 NZ_CP127276:2305663-2305896 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References