Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2242877..2243503 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag QRF08_RS10550 Protein ID WP_003410075.1
Coordinates 2243105..2243503 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag QRF08_RS10545 Protein ID WP_003911750.1
Coordinates 2242877..2243104 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS10535 (QRF08_10535) 2240916..2241260 - 345 WP_003410065.1 ferredoxin family protein -
QRF08_RS10540 (QRF08_10540) 2241449..2242618 - 1170 WP_003899126.1 ATP-binding protein -
QRF08_RS10545 (QRF08_10545) 2242877..2243104 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF08_RS10550 (QRF08_10550) 2243105..2243503 + 399 WP_003410075.1 PIN domain nuclease Toxin
QRF08_RS10555 (QRF08_10555) 2243686..2244117 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
QRF08_RS10560 (QRF08_10560) 2244218..2244652 + 435 WP_003914358.1 DUF1398 domain-containing protein -
QRF08_RS10565 (QRF08_10565) 2245089..2245268 - 180 Protein_2088 hypothetical protein -
QRF08_RS10570 (QRF08_10570) 2245356..2245976 + 621 WP_003410086.1 IS110 family transposase -
QRF08_RS10575 (QRF08_10575) 2245930..2246520 + 591 WP_003899131.1 IS110 family transposase -
QRF08_RS10580 (QRF08_10580) 2246648..2247904 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T283965 WP_003410075.1 NZ_CP127276:2243105-2243503 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT283965 WP_003911750.1 NZ_CP127276:2242877-2243104 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References