Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2210245..2210933 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag QRF08_RS10380 Protein ID WP_003409958.1
Coordinates 2210245..2210664 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag QRF08_RS10385 Protein ID WP_003409968.1
Coordinates 2210673..2210933 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS10360 (QRF08_10360) 2205740..2206588 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
QRF08_RS10365 (QRF08_10365) 2206551..2207996 - 1446 WP_003899115.1 APC family permease -
QRF08_RS10370 (QRF08_10370) 2208175..2208861 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
QRF08_RS10375 (QRF08_10375) 2209052..2210020 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
QRF08_RS10380 (QRF08_10380) 2210245..2210664 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS10385 (QRF08_10385) 2210673..2210933 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF08_RS10390 (QRF08_10390) 2211076..2212752 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
QRF08_RS10395 (QRF08_10395) 2212740..2213393 - 654 WP_003409976.1 cutinase Cfp21 -
QRF08_RS10400 (QRF08_10400) 2213508..2213738 + 231 WP_003409980.1 DUF167 domain-containing protein -
QRF08_RS10405 (QRF08_10405) 2213823..2214734 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
QRF08_RS10410 (QRF08_10410) 2214843..2215442 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T283962 WP_003409958.1 NZ_CP127276:c2210664-2210245 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT283962 WP_003409968.1 NZ_CP127276:c2210933-2210673 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References