Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2188513..2189057 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag QRF08_RS10260 Protein ID WP_003409896.1
Coordinates 2188513..2188809 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag QRF08_RS10265 Protein ID WP_003409899.1
Coordinates 2188806..2189057 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS10205 (QRF08_10205) 2183546..2183896 - 351 WP_003409871.1 hypothetical protein -
QRF08_RS10210 (QRF08_10210) 2183907..2184809 - 903 WP_003899097.1 hypothetical protein -
QRF08_RS10215 (QRF08_10215) 2184830..2185021 - 192 WP_003409876.1 hypothetical protein -
QRF08_RS10220 (QRF08_10220) 2185022..2185318 - 297 WP_003409877.1 hypothetical protein -
QRF08_RS10225 (QRF08_10225) 2185558..2185773 + 216 WP_003409878.1 antitoxin -
QRF08_RS10230 (QRF08_10230) 2185770..2186081 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
QRF08_RS10235 (QRF08_10235) 2186055..2186576 - 522 WP_003904745.1 hypothetical protein -
QRF08_RS10240 (QRF08_10240) 2186551..2186928 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
QRF08_RS10245 (QRF08_10245) 2186970..2187419 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
QRF08_RS10250 (QRF08_10250) 2187416..2187961 + 546 WP_003409891.1 SecB-like chaperone -
QRF08_RS10255 (QRF08_10255) 2187850..2188464 - 615 WP_003901296.1 hypothetical protein -
QRF08_RS10260 (QRF08_10260) 2188513..2188809 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRF08_RS10265 (QRF08_10265) 2188806..2189057 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
QRF08_RS10270 (QRF08_10270) 2189044..2189538 + 495 WP_003899099.1 hypothetical protein -
QRF08_RS10275 (QRF08_10275) 2189698..2190105 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
QRF08_RS10280 (QRF08_10280) 2190109..2190381 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QRF08_RS10285 (QRF08_10285) 2190414..2191634 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
QRF08_RS10290 (QRF08_10290) 2192532..2193329 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T283961 WP_003409896.1 NZ_CP127276:c2188809-2188513 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT283961 WP_003409899.1 NZ_CP127276:c2189057-2188806 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References