Detailed information of TA system TA028396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1567084..1567622
• Replicon: chromosome
• Accession: NC_018697
• Organism: Cycloclasticus sp. P1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: K0C4M4
• Locus tag: Q91_RS07525
• Protein ID: WP_015006290.1
• Coordinates: 1567084..1567380 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: K0C796
• Locus tag: Q91_RS07530
• Protein ID: WP_015006291.1
• Coordinates: 1567377..1567622 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q91_RS07500	1562118..1563896	-	1779	WP_202948160.1	FAD-binding oxidoreductase	-
Q91_RS11430	1564361..1564750	-	390	WP_015006286.1	MAPEG family protein	-
Q91_RS07510	1564788..1565411	-	624	WP_015006287.1	glutathione S-transferase	-
Q91_RS07515	1565453..1565722	-	270	WP_015006288.1	glutaredoxin	-
Q91_RS07520	1565851..1566735	+	885	WP_015006289.1	LysR family transcriptional regulator	-
Q91_RS07525	1567084..1567380	-	297	WP_015006290.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Q91_RS07530	1567377..1567622	-	246	WP_015006291.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
Q91_RS07535	1567915..1569309	+	1395	WP_202948161.1	efflux transporter outer membrane subunit	-
Q91_RS07540	1569299..1570618	+	1320	WP_015006293.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11594.30 Da
• Isoelectric Point: 5.6628

>T28396 WP_015006290.1 NC_018697:c1567380-1567084 [Cycloclasticus sp. P1]
MTTPYRLRSLAQDDLESIWLYTYKEWGITQADTYLGSLIKRFEWLAENALLGRPRDDVKRGYYCYPEGMHLIFYVINNNQ
VEIIGIPHQSMDIVKYLA

Nucleotide

• Length: 297 bp

>T28396 NC_018697:c1567380-1567084 [Cycloclasticus sp. P1]
ATGACAACCCCCTATCGGTTAAGGTCACTTGCGCAAGATGACCTGGAATCTATTTGGCTTTATACCTATAAGGAATGGGG
CATAACGCAAGCAGATACTTACCTTGGCTCATTAATTAAACGTTTCGAGTGGTTAGCTGAAAATGCCTTGTTAGGCAGAC
CAAGAGATGATGTGAAGAGAGGGTACTATTGTTACCCTGAAGGCATGCACCTTATTTTTTACGTTATTAATAACAATCAG
GTCGAGATTATTGGAATACCTCATCAAAGTATGGATATTGTTAAGTATTTGGCGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9255.41 Da
• Isoelectric Point: 7.4049

>AT28396 WP_015006291.1 NC_018697:c1567622-1567377 [Cycloclasticus sp. P1]
MARNTSVTLGEHFDEFVHEKINSGRFQSVSEVVRAGLRKLEEDETKLQVLRDKLQAGENSPLVDDFDGKKFMSGLRSKHH
K

Nucleotide

• Length: 246 bp

>AT28396 NC_018697:c1567622-1567377 [Cycloclasticus sp. P1]
ATGGCAAGAAATACATCAGTAACACTCGGTGAACATTTTGATGAGTTCGTGCATGAGAAAATTAATTCAGGGCGTTTTCA
ATCGGTAAGTGAGGTCGTGCGTGCAGGGCTACGCAAACTTGAAGAGGATGAAACAAAGCTACAGGTGCTTAGAGATAAAT
TACAAGCAGGTGAAAACAGCCCGCTAGTCGATGACTTTGATGGTAAAAAGTTTATGTCGGGGTTGCGTAGCAAGCACCAT
AAATGA

Structures

Toxin

• AlphaFold DB: K0C4M4

Antitoxin

• AlphaFold DB: K0C796