Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2179476..2180179 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag QRF08_RS10170 Protein ID WP_003409778.1
Coordinates 2179476..2179805 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag QRF08_RS10175 Protein ID WP_003409780.1
Coordinates 2179802..2180179 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS10150 (QRF08_10150) 2175859..2176929 + 1071 WP_003902252.1 epoxide hydrolase EphB -
QRF08_RS10155 (QRF08_10155) 2176926..2177441 + 516 WP_003409718.1 flavin reductase family protein -
QRF08_RS10160 (QRF08_10160) 2177438..2178499 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
QRF08_RS10165 (QRF08_10165) 2178496..2179266 + 771 WP_003409775.1 SDR family oxidoreductase -
QRF08_RS10170 (QRF08_10170) 2179476..2179805 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QRF08_RS10175 (QRF08_10175) 2179802..2180179 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
QRF08_RS10180 (QRF08_10180) 2180176..2180766 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
QRF08_RS10185 (QRF08_10185) 2180821..2182185 + 1365 WP_003910878.1 HNH endonuclease signature motif containing protein -
QRF08_RS10190 (QRF08_10190) 2182340..2182792 - 453 WP_003899095.1 lipoprotein -
QRF08_RS10195 (QRF08_10195) 2182856..2183257 + 402 WP_003409869.1 hypothetical protein -
QRF08_RS10200 (QRF08_10200) 2183250..2183432 - 183 WP_003409870.1 hypothetical protein -
QRF08_RS10205 (QRF08_10205) 2183546..2183896 - 351 WP_003409871.1 hypothetical protein -
QRF08_RS10210 (QRF08_10210) 2183907..2184809 - 903 WP_003899097.1 hypothetical protein -
QRF08_RS10215 (QRF08_10215) 2184830..2185021 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T283959 WP_003409778.1 NZ_CP127276:c2179805-2179476 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT283959 WP_003409780.1 NZ_CP127276:c2180179-2179802 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References