Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1957704..1958164 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag QRF08_RS09160 Protein ID WP_003898996.1
Coordinates 1957916..1958164 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag QRF08_RS09155 Protein ID WP_003408528.1
Coordinates 1957704..1957916 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS09140 (QRF08_09140) 1954182..1955369 - 1188 WP_003898992.1 nitrate transporter NarK -
QRF08_RS09145 (QRF08_09145) 1955656..1955940 + 285 WP_003408522.1 DUF1876 domain-containing protein -
QRF08_RS09150 (QRF08_09150) 1955954..1957636 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
QRF08_RS09155 (QRF08_09155) 1957704..1957916 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF08_RS09160 (QRF08_09160) 1957916..1958164 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS09165 (QRF08_09165) 1958172..1958909 + 738 WP_003898997.1 hypothetical protein -
QRF08_RS09170 (QRF08_09170) 1959003..1960703 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
QRF08_RS09175 (QRF08_09175) 1960988..1961389 - 402 WP_003408538.1 hypothetical protein -
QRF08_RS09180 (QRF08_09180) 1961379..1961990 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T283958 WP_003898996.1 NZ_CP127276:1957916-1958164 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT283958 WP_003408528.1 NZ_CP127276:1957704-1957916 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References