Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1937029..1937642 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QRF08_RS09050 Protein ID WP_003910864.1
Coordinates 1937029..1937418 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag QRF08_RS09055 Protein ID WP_003408469.1
Coordinates 1937415..1937642 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS09015 (QRF08_09015) 1932658..1933572 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
QRF08_RS09020 (QRF08_09020) 1933575..1934405 + 831 WP_003408448.1 cyclase family protein -
QRF08_RS09025 (QRF08_09025) 1934405..1934755 + 351 WP_003898986.1 cupin domain-containing protein -
QRF08_RS09030 (QRF08_09030) 1934808..1935626 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
QRF08_RS09035 (QRF08_09035) 1935640..1936419 + 780 WP_003408460.1 IclR family transcriptional regulator -
QRF08_RS09045 (QRF08_09045) 1936850..1936981 + 132 Protein_1784 IS3 family transposase -
QRF08_RS09050 (QRF08_09050) 1937029..1937418 - 390 WP_003910864.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS09055 (QRF08_09055) 1937415..1937642 - 228 WP_003408469.1 antitoxin Antitoxin
QRF08_RS09060 (QRF08_09060) 1937860..1939344 + 1485 WP_003408473.1 biotin carboxylase -
QRF08_RS09065 (QRF08_09065) 1939341..1940588 + 1248 WP_003408476.1 serine hydrolase -
QRF08_RS09070 (QRF08_09070) 1940631..1941050 - 420 WP_003408483.1 hypothetical protein -
QRF08_RS09075 (QRF08_09075) 1941040..1941750 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13837.02 Da        Isoelectric Point: 7.4232

>T283957 WP_003910864.1 NZ_CP127276:c1937418-1937029 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVRAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT283957 WP_003408469.1 NZ_CP127276:c1937642-1937415 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References