Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1763992..1764605 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag QRF08_RS08300 Protein ID WP_003407786.1
Coordinates 1764201..1764605 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag QRF08_RS08295 Protein ID WP_009935474.1
Coordinates 1763992..1764195 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS08265 (QRF08_08265) 1759397..1759777 + 381 WP_003407768.1 fumarate reductase subunit C -
QRF08_RS08270 (QRF08_08270) 1759774..1760151 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
QRF08_RS08275 (QRF08_08275) 1760219..1760827 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
QRF08_RS08280 (QRF08_08280) 1761011..1762159 + 1149 Protein_1633 MMPL family transporter -
QRF08_RS08285 (QRF08_08285) 1762169..1762615 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
QRF08_RS08290 (QRF08_08290) 1762650..1763939 + 1290 WP_003407781.1 threonine ammonia-lyase -
QRF08_RS08295 (QRF08_08295) 1763992..1764195 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF08_RS08300 (QRF08_08300) 1764201..1764605 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
QRF08_RS08305 (QRF08_08305) 1764622..1766364 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
QRF08_RS08310 (QRF08_08310) 1766357..1768654 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T283956 WP_003407786.1 NZ_CP127276:1764201-1764605 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT283956 WP_009935474.1 NZ_CP127276:1763992-1764195 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References