Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1573334..1573989 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag QRF08_RS07455 Protein ID WP_003898861.1
Coordinates 1573334..1573735 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag QRF08_RS07460 Protein ID WP_003407272.1
Coordinates 1573732..1573989 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS07440 (QRF08_07440) 1568806..1570191 - 1386 WP_003407260.1 cytochrome P450 -
QRF08_RS07445 (QRF08_07445) 1570269..1571303 + 1035 WP_003407264.1 AraC family transcriptional regulator -
QRF08_RS07450 (QRF08_07450) 1571349..1573079 - 1731 WP_009940170.1 PE family protein -
QRF08_RS07455 (QRF08_07455) 1573334..1573735 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS07460 (QRF08_07460) 1573732..1573989 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
QRF08_RS07465 (QRF08_07465) 1574072..1575031 - 960 WP_003407276.1 alpha/beta hydrolase -
QRF08_RS07470 (QRF08_07470) 1575056..1576018 - 963 WP_003905554.1 alpha/beta hydrolase -
QRF08_RS07475 (QRF08_07475) 1576017..1576754 + 738 WP_031647000.1 lysoplasmalogenase -
QRF08_RS07480 (QRF08_07480) 1576835..1578802 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T283954 WP_003898861.1 NZ_CP127276:c1573735-1573334 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT283954 WP_003407272.1 NZ_CP127276:c1573989-1573732 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References