Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1537612..1538662 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag QRF08_RS07300 Protein ID WP_003407164.1
Coordinates 1537612..1538433 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag QRF08_RS07305 Protein ID WP_003407167.1
Coordinates 1538426..1538662 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS07280 (QRF08_07280) 1533170..1533832 - 663 WP_003407152.1 membrane protein -
QRF08_RS07285 (QRF08_07285) 1533829..1534614 - 786 WP_003407157.1 membrane protein -
QRF08_RS07290 (QRF08_07290) 1534905..1536866 - 1962 WP_003407159.1 sigma-F factor regulator -
QRF08_RS07295 (QRF08_07295) 1537005..1537391 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
QRF08_RS07300 (QRF08_07300) 1537612..1538433 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
QRF08_RS07305 (QRF08_07305) 1538426..1538662 + 237 WP_003407167.1 hypothetical protein Antitoxin
QRF08_RS07310 (QRF08_07310) 1538734..1539939 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
QRF08_RS07315 (QRF08_07315) 1540242..1541027 + 786 WP_003902048.1 lipoprotein LprF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T283953 WP_003407164.1 NZ_CP127276:1537612-1538433 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT283953 WP_003407167.1 NZ_CP127276:1538426-1538662 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References