Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1383500..1384188 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag QRF08_RS06630 Protein ID WP_003406304.1
Coordinates 1383757..1384188 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag QRF08_RS06625 Protein ID WP_003406302.1
Coordinates 1383500..1383760 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS06605 (QRF08_06605) 1379077..1379901 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
QRF08_RS06610 (QRF08_06610) 1379906..1381087 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
QRF08_RS06615 (QRF08_06615) 1381164..1382264 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
QRF08_RS06620 (QRF08_06620) 1382435..1383424 + 990 WP_003406301.1 malate dehydrogenase -
QRF08_RS06625 (QRF08_06625) 1383500..1383760 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
QRF08_RS06630 (QRF08_06630) 1383757..1384188 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS06635 (QRF08_06635) 1384211..1385899 - 1689 WP_286018102.1 PE family protein -
QRF08_RS06640 (QRF08_06640) 1386079..1386939 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QRF08_RS06645 (QRF08_06645) 1387020..1387850 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QRF08_RS06650 (QRF08_06650) 1387907..1388200 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
QRF08_RS06655 (QRF08_06655) 1388197..1388466 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T283951 WP_003406304.1 NZ_CP127276:1383757-1384188 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT283951 WP_003406302.1 NZ_CP127276:1383500-1383760 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References