Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 72769..73336 Replicon chromosome
Accession NC_018697
Organism Cycloclasticus sp. P1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Q91_RS00335 Protein ID WP_041230465.1
Coordinates 72989..73336 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Q91_RS00330 Protein ID WP_015004879.1
Coordinates 72769..72999 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q91_RS00310 68189..69247 + 1059 WP_015004875.1 uroporphyrinogen decarboxylase -
Q91_RS00315 69287..69583 + 297 WP_148271117.1 SelT/SelW/SelH family protein -
Q91_RS00320 69616..71583 - 1968 WP_050999765.1 tetratricopeptide repeat protein -
Q91_RS00325 71912..72622 - 711 WP_041230464.1 transposase -
Q91_RS00330 72769..72999 + 231 WP_015004879.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
Q91_RS00335 72989..73336 + 348 WP_041230465.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Q91_RS11395 73458..75464 - 2007 WP_015004881.1 type IV pilus modification protein PilV -
Q91_RS00345 75493..76806 - 1314 WP_041230466.1 hypothetical protein -
Q91_RS00350 76812..77471 - 660 WP_015004883.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
Q91_RS11600 77891..77986 - 96 Protein_70 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin

PrlF antitoxin

(6-47)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12770.52 Da        Isoelectric Point: 6.3171

>T28395 WP_041230465.1 NC_018697:72989-73336 [Cycloclasticus sp. P1]
VTFKAFDVVVVPFPFTDRTTTKRRPALVLSNENTFNRKVGQSVLAMITSANNSDWPLDTNIQDLDAAGLPSDSVVRMKLF
TLDDRLVLRKAGQLSSRDKQAAQAALQELLDVEYS

Download         Length: 348 bp

>T28395 NC_018697:72989-73336 [Cycloclasticus sp. P1]
GTGACCTTTAAGGCATTTGATGTCGTCGTTGTACCGTTTCCATTTACAGACCGGACAACAACAAAAAGGCGGCCAGCGTT
AGTCCTATCAAATGAAAATACATTTAATCGCAAGGTGGGGCAATCTGTGTTAGCCATGATAACTAGCGCTAATAACTCAG
ATTGGCCGTTAGATACTAATATTCAAGATTTAGATGCAGCAGGCCTACCATCGGATTCAGTAGTACGAATGAAGCTGTTC
ACATTAGACGATAGACTGGTTCTTCGTAAAGCAGGGCAATTGAGCAGCAGGGATAAACAAGCAGCTCAAGCGGCTCTTCA
AGAATTACTAGATGTTGAGTATAGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8738.95 Da        Isoelectric Point: 5.6864

>AT28395 WP_015004879.1 NC_018697:72769-72999 [Cycloclasticus sp. P1]
MQTATSKLTKKYQATIPEPVRKLLHLKMGDEIAFDIKKDGVHLRRARAVDIAFTQSLENTLSEWMTENDEEAYSDL

Download         Length: 231 bp

>AT28395 NC_018697:72769-72999 [Cycloclasticus sp. P1]
ATGCAAACAGCGACGAGTAAACTAACAAAGAAATACCAAGCAACAATACCAGAACCAGTAAGAAAGCTACTGCATTTGAA
AATGGGTGATGAAATTGCCTTTGATATAAAAAAAGACGGTGTTCACTTACGTAGAGCAAGAGCAGTAGATATAGCCTTCA
CGCAAAGCCTAGAAAACACATTGAGCGAGTGGATGACGGAAAATGATGAAGAGGCATATAGTGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References