Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1023433..1024406 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag QRF08_RS04880 Protein ID WP_003404756.1
Coordinates 1023906..1024406 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag QRF08_RS04875 Protein ID WP_003404754.1
Coordinates 1023433..1023909 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS04855 (QRF08_04855) 1019280..1020551 - 1272 WP_003404747.1 PPE family protein -
QRF08_RS04860 (QRF08_04860) 1020566..1020865 - 300 WP_003404748.1 PE family protein -
QRF08_RS04865 (QRF08_04865) 1021309..1023090 + 1782 WP_003404749.1 BCCT family transporter -
QRF08_RS04870 (QRF08_04870) 1023090..1023344 + 255 WP_234708440.1 hypothetical protein -
QRF08_RS04875 (QRF08_04875) 1023433..1023909 + 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
QRF08_RS04880 (QRF08_04880) 1023906..1024406 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
QRF08_RS04890 (QRF08_04890) 1024719..1026038 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
QRF08_RS04895 (QRF08_04895) 1026326..1026907 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
QRF08_RS04900 (QRF08_04900) 1026907..1028559 + 1653 WP_003905412.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T283947 WP_003404756.1 NZ_CP127276:1023906-1024406 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT283947 WP_003404754.1 NZ_CP127276:1023433-1023909 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References