Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1013903..1014522 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag QRF08_RS04825 Protein ID WP_003404726.1
Coordinates 1014088..1014522 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag QRF08_RS04820 Protein ID WP_003898641.1
Coordinates 1013903..1014082 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS04805 (QRF08_04805) 1009377..1010956 + 1580 Protein_947 serine hydrolase -
QRF08_RS04810 (QRF08_04810) 1010953..1013346 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
QRF08_RS04815 (QRF08_04815) 1013619..1013777 + 159 WP_003404720.1 hypothetical protein -
QRF08_RS04820 (QRF08_04820) 1013903..1014082 + 180 WP_003898641.1 antitoxin Antitoxin
QRF08_RS04825 (QRF08_04825) 1014088..1014522 + 435 WP_003404726.1 SRPBCC family protein Toxin
QRF08_RS04830 (QRF08_04830) 1014620..1015393 + 774 WP_003404735.1 VOC family protein -
QRF08_RS04835 (QRF08_04835) 1015458..1015907 + 450 WP_003404738.1 hypothetical protein -
QRF08_RS04840 (QRF08_04840) 1016042..1016272 - 231 WP_003898642.1 hypothetical protein -
QRF08_RS04845 (QRF08_04845) 1016439..1017947 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
QRF08_RS04850 (QRF08_04850) 1017949..1019187 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T283946 WP_003404726.1 NZ_CP127276:1014088-1014522 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT283946 WP_003898641.1 NZ_CP127276:1013903-1014082 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References