Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 752206..752839 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag QRF08_RS03475 Protein ID WP_003403365.1
Coordinates 752206..752589 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag QRF08_RS03480 Protein ID WP_003403368.1
Coordinates 752684..752839 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS03450 (QRF08_03450) 747498..748034 + 537 WP_003403341.1 50S ribosomal protein L10 -
QRF08_RS03455 (QRF08_03455) 748071..748463 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
QRF08_RS03460 (QRF08_03460) 748456..749151 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
QRF08_RS03465 (QRF08_03465) 749222..750727 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
QRF08_RS03470 (QRF08_03470) 750808..751818 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
QRF08_RS03475 (QRF08_03475) 752206..752589 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
QRF08_RS03480 (QRF08_03480) 752684..752839 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF08_RS03485 (QRF08_03485) 752915..753631 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
QRF08_RS03490 (QRF08_03490) 753907..754215 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
QRF08_RS03495 (QRF08_03495) 754202..754447 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
QRF08_RS03500 (QRF08_03500) 754557..754994 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
QRF08_RS03505 (QRF08_03505) 754991..755245 - 255 WP_003911263.1 antitoxin VapB7 -
QRF08_RS03510 (QRF08_03510) 755359..757722 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T283941 WP_003403365.1 NZ_CP127276:c752589-752206 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT283941 WP_003403368.1 NZ_CP127276:c752839-752684 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References