Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 715632..716281 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag QRF08_RS03290 Protein ID WP_003403236.1
Coordinates 715886..716281 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag QRF08_RS03285 Protein ID WP_003403235.1
Coordinates 715632..715886 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS03260 (QRF08_03260) 710758..710841 + 84 Protein_646 galactose-1-phosphate uridylyltransferase -
QRF08_RS03265 (QRF08_03265) 710860..711941 + 1082 Protein_647 galactose-1-phosphate uridylyltransferase -
QRF08_RS03270 (QRF08_03270) 711938..713029 + 1092 WP_003900977.1 galactokinase -
QRF08_RS03275 (QRF08_03275) 713424..714488 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QRF08_RS03280 (QRF08_03280) 714592..715539 + 948 WP_003403232.1 DUF732 domain-containing protein -
QRF08_RS03285 (QRF08_03285) 715632..715886 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
QRF08_RS03290 (QRF08_03290) 715886..716281 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
QRF08_RS03295 (QRF08_03295) 716375..717115 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
QRF08_RS03300 (QRF08_03300) 717247..717507 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QRF08_RS03305 (QRF08_03305) 717504..717911 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
QRF08_RS03310 (QRF08_03310) 717983..719134 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
QRF08_RS03315 (QRF08_03315) 719227..720954 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T283939 WP_003403236.1 NZ_CP127276:715886-716281 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT283939 WP_003403235.1 NZ_CP127276:715632-715886 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References