Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710004..710629 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag QRF08_RS03255 Protein ID WP_003403218.1
Coordinates 710228..710629 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag QRF08_RS03250 Protein ID WP_003403213.1
Coordinates 710004..710231 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS03225 (QRF08_03225) 705183..705404 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QRF08_RS03230 (QRF08_03230) 705546..706151 + 606 WP_003898526.1 hypothetical protein -
QRF08_RS03235 (QRF08_03235) 706170..708737 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
QRF08_RS03240 (QRF08_03240) 708821..709570 + 750 WP_003898528.1 hypothetical protein -
QRF08_RS03245 (QRF08_03245) 709567..709809 + 243 WP_003403210.1 hypothetical protein -
QRF08_RS03250 (QRF08_03250) 710004..710231 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
QRF08_RS03255 (QRF08_03255) 710228..710629 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
QRF08_RS03260 (QRF08_03260) 710758..710841 + 84 Protein_646 galactose-1-phosphate uridylyltransferase -
QRF08_RS03265 (QRF08_03265) 710860..711941 + 1082 Protein_647 galactose-1-phosphate uridylyltransferase -
QRF08_RS03270 (QRF08_03270) 711938..713029 + 1092 WP_003900977.1 galactokinase -
QRF08_RS03275 (QRF08_03275) 713424..714488 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QRF08_RS03280 (QRF08_03280) 714592..715539 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T283938 WP_003403218.1 NZ_CP127276:710228-710629 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT283938 WP_003403213.1 NZ_CP127276:710004-710231 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References