Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 702466..703109 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag QRF08_RS03205 Protein ID WP_003403187.1
Coordinates 702708..703109 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag QRF08_RS03200 Protein ID WP_003403184.1
Coordinates 702466..702711 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS03165 (QRF08_03165) 697746..698276 - 531 WP_003917320.1 two component system sensor kinase HK2 -
QRF08_RS03170 (QRF08_03170) 698260..698955 - 696 WP_003918099.1 two-component system response regulator TcrA -
QRF08_RS03175 (QRF08_03175) 699078..699389 + 312 WP_003403164.1 hypothetical protein -
QRF08_RS03180 (QRF08_03180) 699461..700411 + 951 WP_003900184.1 DUF1259 domain-containing protein -
QRF08_RS03185 (QRF08_03185) 700652..701236 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
QRF08_RS03190 (QRF08_03190) 701238..701948 + 711 Protein_632 IS607 family element RNA-guided endonuclease TnpB -
QRF08_RS03195 (QRF08_03195) 701951..702421 + 471 WP_003898523.1 hypothetical protein -
QRF08_RS03200 (QRF08_03200) 702466..702711 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF08_RS03205 (QRF08_03205) 702708..703109 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS03210 (QRF08_03210) 703100..703279 + 180 Protein_636 hypothetical protein -
QRF08_RS03215 (QRF08_03215) 703697..703894 - 198 WP_003403191.1 hypothetical protein -
QRF08_RS03220 (QRF08_03220) 703974..705131 - 1158 WP_003898524.1 hypothetical protein -
QRF08_RS03225 (QRF08_03225) 705183..705404 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QRF08_RS03230 (QRF08_03230) 705546..706151 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T283937 WP_003403187.1 NZ_CP127276:702708-703109 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT283937 WP_003403184.1 NZ_CP127276:702466-702711 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References