Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 694061..694707 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag QRF08_RS03135 Protein ID WP_003403122.1
Coordinates 694061..694453 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag QRF08_RS03140 Protein ID WP_003403125.1
Coordinates 694450..694707 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS03120 (QRF08_03120) 689723..691249 + 1527 WP_003403112.1 virulence factor Mce family protein -
QRF08_RS03125 (QRF08_03125) 691312..692454 + 1143 WP_003911253.1 virulence factor Mce family protein -
QRF08_RS03130 (QRF08_03130) 692459..694009 + 1551 WP_003905349.1 MCE family protein -
QRF08_RS03135 (QRF08_03135) 694061..694453 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
QRF08_RS03140 (QRF08_03140) 694450..694707 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
QRF08_RS03145 (QRF08_03145) 694890..696125 - 1236 WP_003403128.1 ATP-binding protein -
QRF08_RS03150 (QRF08_03150) 696376..696789 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
QRF08_RS03155 (QRF08_03155) 696786..697022 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
QRF08_RS03160 (QRF08_03160) 697126..697632 - 507 WP_003900973.1 two component system sensor kinase HK1 -
QRF08_RS03165 (QRF08_03165) 697746..698276 - 531 WP_003917320.1 two component system sensor kinase HK2 -
QRF08_RS03170 (QRF08_03170) 698260..698955 - 696 WP_003918099.1 two-component system response regulator TcrA -
QRF08_RS03175 (QRF08_03175) 699078..699389 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T283935 WP_003403122.1 NZ_CP127276:c694453-694061 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT283935 WP_003403125.1 NZ_CP127276:c694707-694450 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References