Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 639450..640126 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag QRF08_RS02900 Protein ID WP_003898500.1
Coordinates 639450..639863 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag QRF08_RS02905 Protein ID WP_003402915.1
Coordinates 639860..640126 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS02870 (QRF08_02870) 634795..635097 - 303 WP_003402896.1 DUF3349 domain-containing protein -
QRF08_RS02875 (QRF08_02875) 635157..635435 - 279 WP_003402901.1 hypothetical protein -
QRF08_RS02880 (QRF08_02880) 635432..636685 - 1254 WP_003402904.1 inorganic phosphate transporter -
QRF08_RS02885 (QRF08_02885) 636805..637191 - 387 WP_003402907.1 VOC family protein -
QRF08_RS02890 (QRF08_02890) 637254..638138 - 885 WP_003402909.1 SDR family oxidoreductase -
QRF08_RS02895 (QRF08_02895) 638234..639136 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
QRF08_RS02900 (QRF08_02900) 639450..639863 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS02905 (QRF08_02905) 639860..640126 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QRF08_RS02910 (QRF08_02910) 640318..642033 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
QRF08_RS02915 (QRF08_02915) 642111..643715 + 1605 WP_003402920.1 amidohydrolase -
QRF08_RS02920 (QRF08_02920) 643712..644692 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T283933 WP_003898500.1 NZ_CP127276:c639863-639450 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT283933 WP_003402915.1 NZ_CP127276:c640126-639860 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References