Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 362698..363269 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag QRF08_RS01585 Protein ID WP_003401560.1
Coordinates 362698..363000 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag QRF08_RS01590 Protein ID WP_003401563.1
Coordinates 363048..363269 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS01565 (QRF08_01565) 358167..358970 - 804 WP_003401540.1 Stf0 family sulphotransferase -
QRF08_RS01570 (QRF08_01570) 358980..360377 - 1398 WP_003401544.1 sulfatase -
QRF08_RS01575 (QRF08_01575) 360556..362331 + 1776 WP_010886074.1 PE family protein -
QRF08_RS01580 (QRF08_01580) 362474..362701 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
QRF08_RS01585 (QRF08_01585) 362698..363000 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
QRF08_RS01590 (QRF08_01590) 363048..363269 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
QRF08_RS01595 (QRF08_01595) 363266..363691 + 426 WP_003401566.1 PIN domain nuclease -
QRF08_RS01600 (QRF08_01600) 363827..364459 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
QRF08_RS01605 (QRF08_01605) 364456..365364 + 909 WP_003900117.1 protochlorophyllide reductase -
QRF08_RS01610 (QRF08_01610) 365372..365962 - 591 WP_229298012.1 hypothetical protein -
QRF08_RS01615 (QRF08_01615) 365955..366005 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T283930 WP_003401560.1 NZ_CP127276:362698-363000 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT283930 WP_003401563.1 NZ_CP127276:363048-363269 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References