Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3953674..3954263 Replicon chromosome
Accession NC_018695
Organism Burkholderia phenoliruptrix BR3459a

Toxin (Protein)


Gene name hicA Uniprot ID A0A6J5KBD0
Locus tag BUPH_RS17495 Protein ID WP_041745866.1
Coordinates 3953674..3953856 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6J5KAW3
Locus tag BUPH_RS17500 Protein ID WP_028361467.1
Coordinates 3953853..3954263 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUPH_RS17465 3948792..3949523 - 732 WP_015004002.1 flagellar hook assembly protein FlgD -
BUPH_RS17470 3949534..3949959 - 426 WP_028361470.1 flagellar basal body rod protein FlgC -
BUPH_RS17475 3950051..3950542 - 492 WP_013589936.1 flagellar basal body rod protein FlgB -
BUPH_RS17480 3950760..3952343 + 1584 WP_015004004.1 flagellar basal body P-ring formation protein FlgA -
BUPH_RS17485 3952497..3952850 + 354 WP_015004005.1 flagellar biosynthesis anti-sigma factor FlgM -
BUPH_RS17490 3952945..3953391 + 447 WP_015004006.1 flagellar protein FlgN -
BUPH_RS17495 3953674..3953856 + 183 WP_041745866.1 type II toxin-antitoxin system HicA family toxin Toxin
BUPH_RS17500 3953853..3954263 + 411 WP_028361467.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BUPH_RS17505 3954295..3955029 - 735 WP_015004008.1 RNA polymerase sigma factor FliA -
BUPH_RS17510 3955058..3955927 - 870 WP_015004009.1 flagellar biosynthesis protein FlhG -
BUPH_RS17515 3955920..3957950 - 2031 WP_015004010.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6621.72 Da        Isoelectric Point: 11.1776

>T28393 WP_041745866.1 NC_018695:3953674-3953856 [Paraburkholderia phenoliruptrix BR3459a]
MNSAEVVKLIHADGWRLVRISGSHHHFRHALKAGLVTIPHPERDLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T28393 NC_018695:3953674-3953856 [Paraburkholderia phenoliruptrix BR3459a]
ATGAACAGTGCCGAGGTCGTCAAACTGATTCACGCGGATGGCTGGCGGCTTGTCCGGATATCGGGCAGCCATCATCACTT
CCGGCACGCATTGAAAGCCGGGCTCGTGACCATCCCCCATCCCGAAAGGGACCTTCCGCCCGGCACGCTGAACAGCATCT
TGAAACAGGCAGGGCTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14929.86 Da        Isoelectric Point: 4.5945

>AT28393 WP_028361467.1 NC_018695:3953853-3954263 [Paraburkholderia phenoliruptrix BR3459a]
MKNLIFPVAIEPGDAEHAFGVIVPDIPGCHSAGDTLEEAYANAKEAIEAHLDTLLDEGLPIPERRTLDEHRRNPDYAGFT
WGFVTTRNIPALKKAVRINISLPEALVHEIDEYAQARGMSRSAFLALAAEHEMAEA

Download         Length: 411 bp

>AT28393 NC_018695:3953853-3954263 [Paraburkholderia phenoliruptrix BR3459a]
ATGAAAAACTTGATCTTTCCGGTCGCCATCGAGCCAGGCGACGCAGAGCACGCGTTCGGCGTCATCGTGCCGGATATTCC
GGGCTGTCATTCGGCGGGAGATACGCTGGAGGAGGCTTATGCGAACGCGAAAGAGGCGATCGAGGCGCATCTGGACACGC
TGCTCGACGAAGGCTTGCCGATTCCCGAAAGGCGGACGCTAGACGAGCATCGGCGTAATCCTGACTACGCGGGTTTCACG
TGGGGCTTTGTGACCACCCGGAATATTCCCGCGCTGAAGAAGGCGGTTCGCATCAACATCTCGTTACCCGAGGCGCTGGT
GCATGAAATCGACGAATACGCGCAGGCGCGTGGCATGTCGCGTTCTGCTTTTCTCGCGCTCGCCGCCGAGCATGAAATGG
CGGAGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6J5KBD0

Antitoxin

Source ID Structure
AlphaFold DB A0A6J5KAW3

References