Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3158536..3159223 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag QRF09_RS15090 Protein ID WP_003414624.1
Coordinates 3158780..3159223 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag QRF09_RS15085 Protein ID WP_003414620.1
Coordinates 3158536..3158793 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS15065 (QRF09_15065) 3153856..3154710 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
QRF09_RS15070 (QRF09_15070) 3154766..3155929 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
QRF09_RS15075 (QRF09_15075) 3155946..3157160 - 1215 WP_003414610.1 zinc metalloprotease Rip -
QRF09_RS15080 (QRF09_15080) 3157168..3158409 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
QRF09_RS15085 (QRF09_15085) 3158536..3158793 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
QRF09_RS15090 (QRF09_15090) 3158780..3159223 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS15095 (QRF09_15095) 3159303..3159965 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
QRF09_RS15100 (QRF09_15100) 3160061..3160252 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
QRF09_RS15105 (QRF09_15105) 3160584..3162332 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
QRF09_RS15110 (QRF09_15110) 3162428..3163009 + 582 WP_003414644.1 fasciclin domain-containing protein -
QRF09_RS15115 (QRF09_15115) 3163109..3163375 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T283922 WP_003414624.1 NZ_CP127275:3158780-3159223 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT283922 WP_003414620.1 NZ_CP127275:3158536-3158793 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References