Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3152935..3153483 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag QRF09_RS15060 Protein ID WP_003414602.1
Coordinates 3153220..3153483 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag QRF09_RS15055 Protein ID WP_003414599.1
Coordinates 3152935..3153216 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS15030 (QRF09_15030) 3148558..3149415 - 858 WP_003899513.1 type I methionyl aminopeptidase -
QRF09_RS15035 (QRF09_15035) 3149457..3150041 - 585 WP_003414585.1 DUF1707 domain-containing protein -
QRF09_RS15040 (QRF09_15040) 3150145..3150393 + 249 WP_003913411.1 antitoxin VapB23 -
QRF09_RS15045 (QRF09_15045) 3150390..3150770 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
QRF09_RS15050 (QRF09_15050) 3150852..3152663 - 1812 WP_003414596.1 penicillin-binding protein -
QRF09_RS15055 (QRF09_15055) 3152935..3153216 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
QRF09_RS15060 (QRF09_15060) 3153220..3153483 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRF09_RS15065 (QRF09_15065) 3153856..3154710 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
QRF09_RS15070 (QRF09_15070) 3154766..3155929 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
QRF09_RS15075 (QRF09_15075) 3155946..3157160 - 1215 WP_003414610.1 zinc metalloprotease Rip -
QRF09_RS15080 (QRF09_15080) 3157168..3158409 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T283921 WP_003414602.1 NZ_CP127275:3153220-3153483 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT283921 WP_003414599.1 NZ_CP127275:3152935-3153216 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References