Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 3903237..3903979 Replicon chromosome
Accession NC_018695
Organism Burkholderia phenoliruptrix BR3459a

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BUPH_RS17255 Protein ID WP_015003970.1
Coordinates 3903614..3903979 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BUPH_RS17250 Protein ID WP_015003969.1
Coordinates 3903237..3903617 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUPH_RS17230 3898473..3899225 + 753 WP_013589888.1 5-oxoprolinase subunit PxpA -
BUPH_RS17235 3899505..3900254 + 750 WP_041746416.1 DUF969 domain-containing protein -
BUPH_RS17240 3900251..3901207 + 957 WP_013589890.1 DUF979 domain-containing protein -
BUPH_RS17245 3901432..3903240 + 1809 WP_015003968.1 tetratricopeptide repeat protein -
BUPH_RS17250 3903237..3903617 + 381 WP_015003969.1 AbrB family transcriptional regulator Antitoxin
BUPH_RS17255 3903614..3903979 + 366 WP_015003970.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BUPH_RS17260 3904015..3905178 - 1164 WP_015003971.1 TraB/GumN family protein -
BUPH_RS17265 3905171..3906190 - 1020 WP_013589895.1 ABC transporter ATP-binding protein -
BUPH_RS17270 3906187..3907194 - 1008 WP_015003972.1 ABC transporter ATP-binding protein -
BUPH_RS17275 3907195..3908112 - 918 WP_013589897.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13281.20 Da        Isoelectric Point: 7.9349

>T28392 WP_015003970.1 NC_018695:3903614-3903979 [Paraburkholderia phenoliruptrix BR3459a]
MMVKRNTPRRGDVYWIDPNPVAGKEMKDRHRFVVITPAEINALGVCMTVPITTGGNFFRHAGLAVHISGHDTTGIAVCNQ
VRTFDINARVEHGSARYVETLDKQTADEIVARVVSAIDPAP

Download         Length: 366 bp

>T28392 NC_018695:3903614-3903979 [Paraburkholderia phenoliruptrix BR3459a]
ATGATGGTCAAGCGGAATACGCCACGGCGCGGCGACGTCTACTGGATCGACCCGAACCCCGTAGCAGGCAAGGAGATGAA
GGACCGGCACCGCTTCGTCGTGATCACGCCCGCCGAGATCAACGCGCTGGGTGTATGTATGACGGTGCCTATCACCACCG
GCGGCAACTTCTTCCGTCACGCCGGCCTTGCCGTCCACATTTCCGGACACGATACAACCGGCATAGCGGTATGCAATCAG
GTTCGCACTTTCGACATCAATGCTCGCGTAGAGCACGGTTCTGCTCGCTACGTAGAGACGCTCGACAAGCAAACAGCCGA
CGAGATCGTTGCGCGAGTAGTCAGCGCAATCGACCCCGCGCCGTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13508.48 Da        Isoelectric Point: 7.5264

>AT28392 WP_015003969.1 NC_018695:3903237-3903617 [Paraburkholderia phenoliruptrix BR3459a]
MKAPRFKAFDVPHGRLSRRSNVLHLLHIHGSAASGEETMAVTSKIRRQGGALVMTIPPALLKLLHVDAGDHMSLEVQDGQ
LIARPASSATKRYTLAELLEGSESIAELTAETAWARDGGPMGSELT

Download         Length: 381 bp

>AT28392 NC_018695:3903237-3903617 [Paraburkholderia phenoliruptrix BR3459a]
ATGAAAGCACCGCGCTTCAAAGCGTTCGATGTACCGCACGGCCGGCTGTCGCGTCGCAGTAATGTGCTACATTTGTTGCA
CATTCACGGCTCGGCGGCGAGCGGAGAAGAGACCATGGCTGTTACATCGAAAATTCGGAGGCAGGGCGGAGCACTTGTCA
TGACGATCCCGCCAGCGCTTCTCAAGTTGCTGCACGTAGACGCCGGAGATCACATGTCCTTGGAGGTCCAGGATGGACAA
TTGATCGCGCGGCCCGCGTCGTCGGCGACAAAACGCTATACGCTCGCCGAACTGCTGGAGGGCTCCGAAAGTATCGCGGA
GTTGACCGCAGAGACCGCCTGGGCACGAGACGGCGGCCCTATGGGAAGCGAGCTGACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References