Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2848836..2849473 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag QRF09_RS13415 Protein ID WP_003413180.1
Coordinates 2848836..2849231 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag QRF09_RS13420 Protein ID WP_003413183.1
Coordinates 2849228..2849473 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS13375 (QRF09_13375) 2844239..2845450 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
QRF09_RS13380 (QRF09_13380) 2845577..2846236 + 660 WP_285978957.1 LppA family lipoprotein -
QRF09_RS13385 (QRF09_13385) 2846233..2846895 + 663 WP_285978958.1 LppA family lipoprotein -
QRF09_RS13390 (QRF09_13390) 2846892..2847170 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
QRF09_RS13395 (QRF09_13395) 2847263..2847676 + 414 WP_003413164.1 PIN domain nuclease -
QRF09_RS13400 (QRF09_13400) 2847715..2847972 + 258 WP_003413167.1 CopG family transcriptional regulator -
QRF09_RS13405 (QRF09_13405) 2847969..2848346 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
QRF09_RS13410 (QRF09_13410) 2848362..2848736 - 375 WP_003413177.1 hypothetical protein -
QRF09_RS13415 (QRF09_13415) 2848836..2849231 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
QRF09_RS13420 (QRF09_13420) 2849228..2849473 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
QRF09_RS13425 (QRF09_13425) 2849884..2850303 - 420 WP_003413190.1 A24 family peptidase -
QRF09_RS13430 (QRF09_13430) 2850315..2851124 - 810 WP_003413193.1 shikimate dehydrogenase -
QRF09_RS13435 (QRF09_13435) 2851121..2852374 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
QRF09_RS13440 (QRF09_13440) 2852367..2852879 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T283913 WP_003413180.1 NZ_CP127275:c2849231-2848836 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT283913 WP_003413183.1 NZ_CP127275:c2849473-2849228 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References