Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2300853..2301489 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag QRF09_RS10790 Protein ID WP_003410654.1
Coordinates 2301079..2301489 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag QRF09_RS10785 Protein ID WP_003410651.1
Coordinates 2300853..2301086 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS10770 (QRF09_10770) 2296310..2296702 + 393 WP_229303073.1 metal ABC transporter permease -
QRF09_RS10775 (QRF09_10775) 2296703..2297107 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
QRF09_RS10780 (QRF09_10780) 2297191..2300775 - 3585 WP_003910889.1 cobaltochelatase subunit CobN -
QRF09_RS10785 (QRF09_10785) 2300853..2301086 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
QRF09_RS10790 (QRF09_10790) 2301079..2301489 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
QRF09_RS10795 (QRF09_10795) 2301473..2302564 + 1092 WP_003900454.1 precorrin-3B synthase -
QRF09_RS10800 (QRF09_10800) 2302574..2303200 + 627 WP_003410658.1 precorrin-8X methylmutase -
QRF09_RS10805 (QRF09_10805) 2303197..2304723 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
QRF09_RS10810 (QRF09_10810) 2304669..2305892 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T283906 WP_003410654.1 NZ_CP127275:2301079-2301489 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT283906 WP_003410651.1 NZ_CP127275:2300853-2301086 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References