Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2238067..2238693 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag QRF09_RS10510 Protein ID WP_003410075.1
Coordinates 2238295..2238693 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag QRF09_RS10505 Protein ID WP_003911750.1
Coordinates 2238067..2238294 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS10495 (QRF09_10495) 2236106..2236450 - 345 WP_003410065.1 ferredoxin family protein -
QRF09_RS10500 (QRF09_10500) 2236639..2237808 - 1170 WP_003899126.1 ATP-binding protein -
QRF09_RS10505 (QRF09_10505) 2238067..2238294 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF09_RS10510 (QRF09_10510) 2238295..2238693 + 399 WP_003410075.1 PIN domain nuclease Toxin
QRF09_RS10515 (QRF09_10515) 2238876..2239307 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
QRF09_RS10520 (QRF09_10520) 2239408..2239842 + 435 WP_003914358.1 DUF1398 domain-containing protein -
QRF09_RS10525 (QRF09_10525) 2240279..2240458 - 180 Protein_2080 hypothetical protein -
QRF09_RS10530 (QRF09_10530) 2240546..2241166 + 621 WP_003410086.1 IS110 family transposase -
QRF09_RS10535 (QRF09_10535) 2241120..2241710 + 591 WP_003899131.1 IS110 family transposase -
QRF09_RS10540 (QRF09_10540) 2241838..2243094 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T283904 WP_003410075.1 NZ_CP127275:2238295-2238693 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT283904 WP_003911750.1 NZ_CP127275:2238067-2238294 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References