Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1761040..1761653 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag QRF09_RS08275 Protein ID WP_003407786.1
Coordinates 1761249..1761653 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag QRF09_RS08270 Protein ID WP_009935474.1
Coordinates 1761040..1761243 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS08240 (QRF09_08240) 1756445..1756825 + 381 WP_003407768.1 fumarate reductase subunit C -
QRF09_RS08245 (QRF09_08245) 1756822..1757199 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
QRF09_RS08250 (QRF09_08250) 1757267..1757875 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
QRF09_RS08255 (QRF09_08255) 1758059..1759207 + 1149 Protein_1628 MMPL family transporter -
QRF09_RS08260 (QRF09_08260) 1759217..1759663 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
QRF09_RS08265 (QRF09_08265) 1759698..1760987 + 1290 WP_003407781.1 threonine ammonia-lyase -
QRF09_RS08270 (QRF09_08270) 1761040..1761243 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF09_RS08275 (QRF09_08275) 1761249..1761653 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
QRF09_RS08280 (QRF09_08280) 1761670..1763412 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
QRF09_RS08285 (QRF09_08285) 1763405..1765702 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T283895 WP_003407786.1 NZ_CP127275:1761249-1761653 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT283895 WP_009935474.1 NZ_CP127275:1761040-1761243 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References