Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1570382..1571037 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag QRF09_RS07430 Protein ID WP_003898861.1
Coordinates 1570382..1570783 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag QRF09_RS07435 Protein ID WP_003407272.1
Coordinates 1570780..1571037 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS07415 (QRF09_07415) 1565854..1567239 - 1386 WP_003407260.1 cytochrome P450 -
QRF09_RS07420 (QRF09_07420) 1567317..1568351 + 1035 WP_003407264.1 AraC family transcriptional regulator -
QRF09_RS07425 (QRF09_07425) 1568397..1570127 - 1731 WP_009940170.1 PE family protein -
QRF09_RS07430 (QRF09_07430) 1570382..1570783 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS07435 (QRF09_07435) 1570780..1571037 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
QRF09_RS07440 (QRF09_07440) 1571120..1572079 - 960 WP_003407276.1 alpha/beta hydrolase -
QRF09_RS07445 (QRF09_07445) 1572104..1573066 - 963 WP_003905554.1 alpha/beta hydrolase -
QRF09_RS07450 (QRF09_07450) 1573065..1573802 + 738 WP_031647000.1 lysoplasmalogenase -
QRF09_RS07455 (QRF09_07455) 1573883..1575850 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T283893 WP_003898861.1 NZ_CP127275:c1570783-1570382 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT283893 WP_003407272.1 NZ_CP127275:c1571037-1570780 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References