Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1534660..1535710 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag QRF09_RS07275 Protein ID WP_003407164.1
Coordinates 1534660..1535481 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag QRF09_RS07280 Protein ID WP_003407167.1
Coordinates 1535474..1535710 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS07255 (QRF09_07255) 1530218..1530880 - 663 WP_003407152.1 membrane protein -
QRF09_RS07260 (QRF09_07260) 1530877..1531662 - 786 WP_003407157.1 membrane protein -
QRF09_RS07265 (QRF09_07265) 1531953..1533914 - 1962 WP_003407159.1 sigma-F factor regulator -
QRF09_RS07270 (QRF09_07270) 1534053..1534439 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
QRF09_RS07275 (QRF09_07275) 1534660..1535481 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
QRF09_RS07280 (QRF09_07280) 1535474..1535710 + 237 WP_003407167.1 hypothetical protein Antitoxin
QRF09_RS07285 (QRF09_07285) 1535782..1536987 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
QRF09_RS07290 (QRF09_07290) 1537290..1538075 + 786 WP_003902048.1 lipoprotein LprF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T283892 WP_003407164.1 NZ_CP127275:1534660-1535481 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT283892 WP_003407167.1 NZ_CP127275:1535474-1535710 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References