Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1384971..1385530 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag QRF09_RS06625 Protein ID WP_003898789.1
Coordinates 1384971..1385264 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag QRF09_RS06630 Protein ID WP_003406322.1
Coordinates 1385261..1385530 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS06600 (QRF09_06600) 1380591..1380851 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
QRF09_RS06605 (QRF09_06605) 1380848..1381279 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
QRF09_RS06610 (QRF09_06610) 1381302..1382963 - 1662 WP_285978982.1 PE family protein -
QRF09_RS06615 (QRF09_06615) 1383143..1384003 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
QRF09_RS06620 (QRF09_06620) 1384084..1384914 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
QRF09_RS06625 (QRF09_06625) 1384971..1385264 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QRF09_RS06630 (QRF09_06630) 1385261..1385530 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRF09_RS06635 (QRF09_06635) 1385643..1389338 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
QRF09_RS06640 (QRF09_06640) 1389480..1390268 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T283891 WP_003898789.1 NZ_CP127275:c1385264-1384971 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT283891 WP_003406322.1 NZ_CP127275:c1385530-1385261 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References