Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 837388..838097 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag QRF09_RS03955 Protein ID WP_003403837.1
Coordinates 837669..838097 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag QRF09_RS03950 Protein ID WP_003403834.1
Coordinates 837388..837645 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS03945 (QRF09_03945) 834919..837297 + 2379 WP_285978975.1 PE family protein -
QRF09_RS03950 (QRF09_03950) 837388..837645 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
QRF09_RS03955 (QRF09_03955) 837669..838097 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS03960 (QRF09_03960) 838178..838315 - 138 WP_003403839.1 hypothetical protein -
QRF09_RS03965 (QRF09_03965) 838474..838719 + 246 WP_003403841.1 hypothetical protein -
QRF09_RS03970 (QRF09_03970) 838788..839672 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
QRF09_RS03975 (QRF09_03975) 839683..840855 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
QRF09_RS03980 (QRF09_03980) 840862..842394 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T283884 WP_003403837.1 NZ_CP127275:837669-838097 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT283884 WP_003403834.1 NZ_CP127275:837388-837645 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References