Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 751852..752540 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag QRF09_RS03475 Protein ID WP_003403386.1
Coordinates 751852..752289 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag QRF09_RS03480 Protein ID WP_003911263.1
Coordinates 752286..752540 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS03445 (QRF09_03445) 748103..749113 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
QRF09_RS03450 (QRF09_03450) 749501..749884 - 384 WP_003403365.1 ribonuclease VapC6 -
QRF09_RS03455 (QRF09_03455) 749979..750134 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
QRF09_RS03460 (QRF09_03460) 750210..750926 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
QRF09_RS03465 (QRF09_03465) 751202..751510 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
QRF09_RS03470 (QRF09_03470) 751497..751742 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
QRF09_RS03475 (QRF09_03475) 751852..752289 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS03480 (QRF09_03480) 752286..752540 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
QRF09_RS03485 (QRF09_03485) 752654..755017 + 2364 WP_003901895.1 arylsulfatase AtsD -
QRF09_RS03490 (QRF09_03490) 755080..755406 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QRF09_RS03495 (QRF09_03495) 755318..755656 + 339 WP_003403405.1 PIN domain-containing protein -
QRF09_RS03500 (QRF09_03500) 755653..755826 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T283883 WP_003403386.1 NZ_CP127275:c752289-751852 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT283883 WP_003911263.1 NZ_CP127275:c752540-752286 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References