Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 707299..707924 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag QRF09_RS03230 Protein ID WP_003403218.1
Coordinates 707523..707924 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag QRF09_RS03225 Protein ID WP_003403213.1
Coordinates 707299..707526 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS03200 (QRF09_03200) 702478..702699 - 222 WP_003898525.1 DUF4926 domain-containing protein -
QRF09_RS03205 (QRF09_03205) 702841..703446 + 606 WP_003898526.1 hypothetical protein -
QRF09_RS03210 (QRF09_03210) 703465..706032 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
QRF09_RS03215 (QRF09_03215) 706116..706865 + 750 WP_003898528.1 hypothetical protein -
QRF09_RS03220 (QRF09_03220) 706862..707104 + 243 WP_003403210.1 hypothetical protein -
QRF09_RS03225 (QRF09_03225) 707299..707526 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
QRF09_RS03230 (QRF09_03230) 707523..707924 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
QRF09_RS03235 (QRF09_03235) 708053..708136 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
QRF09_RS03240 (QRF09_03240) 708155..709236 + 1082 Protein_642 galactose-1-phosphate uridylyltransferase -
QRF09_RS03245 (QRF09_03245) 709233..710324 + 1092 WP_003900977.1 galactokinase -
QRF09_RS03250 (QRF09_03250) 710719..711783 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QRF09_RS03255 (QRF09_03255) 711887..712834 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T283877 WP_003403218.1 NZ_CP127275:707523-707924 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT283877 WP_003403213.1 NZ_CP127275:707299-707526 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References