Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 691356..692002 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag QRF09_RS03110 Protein ID WP_003403122.1
Coordinates 691356..691748 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag QRF09_RS03115 Protein ID WP_003403125.1
Coordinates 691745..692002 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS03095 (QRF09_03095) 687018..688544 + 1527 WP_285978974.1 virulence factor Mce family protein -
QRF09_RS03100 (QRF09_03100) 688607..689749 + 1143 WP_003911253.1 virulence factor Mce family protein -
QRF09_RS03105 (QRF09_03105) 689754..691304 + 1551 WP_003905349.1 MCE family protein -
QRF09_RS03110 (QRF09_03110) 691356..691748 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
QRF09_RS03115 (QRF09_03115) 691745..692002 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
QRF09_RS03120 (QRF09_03120) 692185..693420 - 1236 WP_003403128.1 ATP-binding protein -
QRF09_RS03125 (QRF09_03125) 693671..694084 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
QRF09_RS03130 (QRF09_03130) 694081..694317 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
QRF09_RS03135 (QRF09_03135) 694421..694927 - 507 WP_003900973.1 two component system sensor kinase HK1 -
QRF09_RS03140 (QRF09_03140) 695041..695571 - 531 WP_003917320.1 two component system sensor kinase HK2 -
QRF09_RS03145 (QRF09_03145) 695555..696250 - 696 WP_003918099.1 two-component system response regulator TcrA -
QRF09_RS03150 (QRF09_03150) 696373..696684 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T283874 WP_003403122.1 NZ_CP127275:c691748-691356 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT283874 WP_003403125.1 NZ_CP127275:c692002-691745 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References