Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 636745..637421 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag QRF09_RS02875 Protein ID WP_003898500.1
Coordinates 636745..637158 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag QRF09_RS02880 Protein ID WP_003402915.1
Coordinates 637155..637421 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS02845 (QRF09_02845) 632090..632392 - 303 WP_003402896.1 DUF3349 domain-containing protein -
QRF09_RS02850 (QRF09_02850) 632452..632730 - 279 WP_003402901.1 hypothetical protein -
QRF09_RS02855 (QRF09_02855) 632727..633980 - 1254 WP_003402904.1 inorganic phosphate transporter -
QRF09_RS02860 (QRF09_02860) 634100..634486 - 387 WP_003402907.1 VOC family protein -
QRF09_RS02865 (QRF09_02865) 634549..635433 - 885 WP_003402909.1 SDR family oxidoreductase -
QRF09_RS02870 (QRF09_02870) 635529..636431 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
QRF09_RS02875 (QRF09_02875) 636745..637158 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS02880 (QRF09_02880) 637155..637421 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QRF09_RS02885 (QRF09_02885) 637613..639328 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
QRF09_RS02890 (QRF09_02890) 639406..641010 + 1605 WP_003402920.1 amidohydrolase -
QRF09_RS02895 (QRF09_02895) 641007..641987 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T283872 WP_003898500.1 NZ_CP127275:c637158-636745 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT283872 WP_003402915.1 NZ_CP127275:c637421-637155 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References