Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 440748..441759 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag QRF09_RS01910 Protein ID WP_003401859.1
Coordinates 440748..441341 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag QRF09_RS01915 Protein ID WP_003401860.1
Coordinates 441370..441759 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS01890 (QRF09_01890) 436397..437779 + 1383 WP_003898415.1 magnesium transporter -
QRF09_RS01895 (QRF09_01895) 437791..438825 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
QRF09_RS01900 (QRF09_01900) 438921..439604 + 684 WP_003401857.1 VTT domain-containing protein -
QRF09_RS01905 (QRF09_01905) 439593..440723 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
QRF09_RS01910 (QRF09_01910) 440748..441341 - 594 WP_003401859.1 zeta toxin family protein Toxin
QRF09_RS01915 (QRF09_01915) 441370..441759 - 390 WP_003401860.1 hypothetical protein Antitoxin
QRF09_RS01920 (QRF09_01920) 441840..443051 - 1212 WP_003401861.1 VWA domain-containing protein -
QRF09_RS01925 (QRF09_01925) 443057..443659 - 603 WP_003898417.1 SRPBCC family protein -
QRF09_RS01930 (QRF09_01930) 443673..444569 - 897 WP_003898418.1 MoxR family ATPase -
QRF09_RS01935 (QRF09_01935) 444566..445159 - 594 WP_003401864.1 NTP transferase domain-containing protein -
QRF09_RS01940 (QRF09_01940) 445156..445911 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T283871 WP_003401859.1 NZ_CP127275:c441341-440748 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT283871 WP_003401860.1 NZ_CP127275:c441759-441370 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References