Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3810158..3810843 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag QRF10_RS17965 Protein ID WP_003417998.1
Coordinates 3810433..3810843 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QRF10_RS17960 Protein ID WP_003912220.1
Coordinates 3810158..3810436 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS17940 (QRF10_17940) 3806147..3807748 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
QRF10_RS17945 (QRF10_17945) 3807765..3808469 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
QRF10_RS17950 (QRF10_17950) 3808587..3809153 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
QRF10_RS17955 (QRF10_17955) 3809215..3810102 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
QRF10_RS17960 (QRF10_17960) 3810158..3810436 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRF10_RS17965 (QRF10_17965) 3810433..3810843 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS17970 (QRF10_17970) 3810876..3812612 - 1737 WP_003418002.1 cholesterol oxidase -
QRF10_RS17975 (QRF10_17975) 3812668..3813795 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
QRF10_RS17980 (QRF10_17980) 3813815..3815404 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T283866 WP_003417998.1 NZ_CP127274:3810433-3810843 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT283866 WP_003912220.1 NZ_CP127274:3810158-3810436 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References