Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3754658..3755187 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag QRF10_RS17705 Protein ID WP_003417760.1
Coordinates 3754930..3755187 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag QRF10_RS17700 Protein ID WP_003417757.1
Coordinates 3754658..3754933 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS17665 (QRF10_17665) 3751231..3751920 - 690 WP_003917774.1 BBE domain-containing protein -
QRF10_RS17670 (QRF10_17670) 3752107..3752478 - 372 WP_003417739.1 FAD-binding protein -
QRF10_RS17675 (QRF10_17675) 3752376..3752594 - 219 WP_157132559.1 hypothetical protein -
QRF10_RS17680 (QRF10_17680) 3752621..3752881 - 261 WP_003417741.1 hypothetical protein -
QRF10_RS17685 (QRF10_17685) 3752996..3753385 + 390 WP_003417745.1 DUF732 domain-containing protein -
QRF10_RS17690 (QRF10_17690) 3753399..3753692 - 294 WP_003417749.1 DUF3017 domain-containing protein -
QRF10_RS17695 (QRF10_17695) 3753689..3754534 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
QRF10_RS17700 (QRF10_17700) 3754658..3754933 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
QRF10_RS17705 (QRF10_17705) 3754930..3755187 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
QRF10_RS17710 (QRF10_17710) 3755229..3756419 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
QRF10_RS17715 (QRF10_17715) 3756536..3756904 + 369 WP_003417765.1 FHA domain-containing protein -
QRF10_RS17720 (QRF10_17720) 3756901..3757452 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
QRF10_RS17725 (QRF10_17725) 3757459..3758040 - 582 WP_003417769.1 ATP/GTP-binding protein -
QRF10_RS17730 (QRF10_17730) 3758021..3758389 - 369 WP_003417772.1 DUF742 domain-containing protein -
QRF10_RS17735 (QRF10_17735) 3758367..3758759 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T283864 WP_003417760.1 NZ_CP127274:3754930-3755187 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT283864 WP_003417757.1 NZ_CP127274:3754658-3754933 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References