Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3167023..3167710 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag QRF10_RS15130 Protein ID WP_003414624.1
Coordinates 3167267..3167710 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag QRF10_RS15125 Protein ID WP_003414620.1
Coordinates 3167023..3167280 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS15105 (QRF10_15105) 3162343..3163197 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
QRF10_RS15110 (QRF10_15110) 3163253..3164416 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
QRF10_RS15115 (QRF10_15115) 3164433..3165647 - 1215 WP_003899518.1 zinc metalloprotease Rip -
QRF10_RS15120 (QRF10_15120) 3165655..3166896 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
QRF10_RS15125 (QRF10_15125) 3167023..3167280 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
QRF10_RS15130 (QRF10_15130) 3167267..3167710 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS15135 (QRF10_15135) 3167790..3168452 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
QRF10_RS15140 (QRF10_15140) 3168548..3168739 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
QRF10_RS15145 (QRF10_15145) 3169071..3170819 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
QRF10_RS15150 (QRF10_15150) 3170915..3171496 + 582 WP_003414644.1 fasciclin domain-containing protein -
QRF10_RS15155 (QRF10_15155) 3171596..3171862 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T283861 WP_003414624.1 NZ_CP127274:3167267-3167710 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT283861 WP_003414620.1 NZ_CP127274:3167023-3167280 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References