Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3120505..3121109 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag QRF10_RS14900 Protein ID WP_003414492.1
Coordinates 3120505..3120897 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag QRF10_RS14905 Protein ID WP_003414495.1
Coordinates 3120894..3121109 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS14870 (QRF10_14870) 3115655..3116443 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
QRF10_RS14875 (QRF10_14875) 3116777..3117322 - 546 WP_003913758.1 DUF1802 family protein -
QRF10_RS14880 (QRF10_14880) 3117594..3118478 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
QRF10_RS14885 (QRF10_14885) 3118481..3119368 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
QRF10_RS14890 (QRF10_14890) 3119673..3120218 - 546 WP_003913758.1 DUF1802 family protein -
QRF10_RS14895 (QRF10_14895) 3120215..3120484 - 270 WP_003912856.1 DUF2277 family protein -
QRF10_RS14900 (QRF10_14900) 3120505..3120897 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS14905 (QRF10_14905) 3120894..3121109 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRF10_RS14910 (QRF10_14910) 3121156..3121905 + 750 WP_003414497.1 enoyl-CoA hydratase -
QRF10_RS14915 (QRF10_14915) 3121984..3123066 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
QRF10_RS14920 (QRF10_14920) 3123059..3124369 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
QRF10_RS14925 (QRF10_14925) 3124372..3125199 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
QRF10_RS14930 (QRF10_14930) 3125196..3126107 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T283859 WP_003414492.1 NZ_CP127274:c3120897-3120505 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT283859 WP_003414495.1 NZ_CP127274:c3121109-3120894 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References