Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3054517..3055204 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag QRF10_RS14535 Protein ID WP_003414064.1
Coordinates 3054809..3055204 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag QRF10_RS14530 Protein ID WP_003414061.1
Coordinates 3054517..3054783 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS14505 (QRF10_14505) 3050156..3051058 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
QRF10_RS14510 (QRF10_14510) 3051127..3051879 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
QRF10_RS14515 (QRF10_14515) 3052123..3052398 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
QRF10_RS14520 (QRF10_14520) 3052395..3054017 - 1623 WP_003906897.1 class I SAM-dependent DNA methyltransferase -
QRF10_RS14525 (QRF10_14525) 3054104..3054520 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 -
QRF10_RS14530 (QRF10_14530) 3054517..3054783 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRF10_RS14535 (QRF10_14535) 3054809..3055204 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS14540 (QRF10_14540) 3055201..3055470 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
QRF10_RS14545 (QRF10_14545) 3055480..3056574 - 1095 WP_003414068.1 restriction endonuclease subunit S -
QRF10_RS14550 (QRF10_14550) 3056571..3056990 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
QRF10_RS14555 (QRF10_14555) 3056989..3057063 + 75 Protein_2872 hypothetical protein -
QRF10_RS14560 (QRF10_14560) 3057064..3057543 - 480 WP_003414073.1 dihydrofolate reductase -
QRF10_RS14565 (QRF10_14565) 3057614..3058414 - 801 WP_286018039.1 thymidylate synthase -
QRF10_RS14570 (QRF10_14570) 3058570..3059307 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T283856 WP_003414064.1 NZ_CP127274:c3055204-3054809 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT283856 WP_003414061.1 NZ_CP127274:c3054783-3054517 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TF65

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References