Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2792017..2792669 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag QRF10_RS13140 Protein ID WP_003412752.1
Coordinates 2792244..2792669 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag QRF10_RS13135 Protein ID WP_003412749.1
Coordinates 2792017..2792238 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS13120 (QRF10_13120) 2790257..2790463 - 207 WP_003899347.1 hypothetical protein -
QRF10_RS13125 (QRF10_13125) 2790599..2791222 + 624 WP_003900858.1 TIGR00725 family protein -
QRF10_RS13130 (QRF10_13130) 2791212..2791964 + 753 WP_003900859.1 hypothetical protein -
QRF10_RS13135 (QRF10_13135) 2792017..2792238 + 222 WP_003412749.1 antitoxin Antitoxin
QRF10_RS13140 (QRF10_13140) 2792244..2792669 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF10_RS13145 (QRF10_13145) 2792692..2793873 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
QRF10_RS13150 (QRF10_13150) 2793870..2794916 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
QRF10_RS13155 (QRF10_13155) 2794927..2796030 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
QRF10_RS13160 (QRF10_13160) 2796289..2797110 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
QRF10_RS13165 (QRF10_13165) 2797107..2797664 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T283848 WP_003412752.1 NZ_CP127274:2792244-2792669 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT283848 WP_003412749.1 NZ_CP127274:2792017-2792238 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References